The Revised Malawi National Strategic Plan for HIV and AIDS 2023–2027 is a multi-sectoral approach aimed at eliminating AIDS as a public health threat by 2030. Building on previous achievements and aligned with global and national frameworks, it focuses on reducing new infections, cutting AIDS-related deaths, and virtually eliminating mother-to-child transmission. The plan addresses key challenges through eight thematic areas, including prevention, testing, treatment, and support for vulnerable groups, while integrating sustainable health systems and community resilience. The NSP, requiring an estimated $1.41 billion over five years, emphasizes a collaborative approach with strong leadership and partnership from local and international stakeholders.